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Syndactyly type 5
1 OMIM reference -
1 associated gene
7 connected diseases
8 signs/symptoms
Disease Type of connection
Brachydactyly type E
Brachydactyly-syndactyly, Zhao type
Synpolydactyly type 1
VACTERL / VATER association
Acute myeloid leukemia with t(8;16)(p11;p13) translocation
Rubinstein-Taybi syndrome due to 16p13.3 microdeletion
Rubinstein-Taybi syndrome due to CREBBP mutations
Synonym(s):
- Postaxial syndactyly with metacarpal synostosis
- SD5
Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare genetic disease
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: neonatal/infancy
Average age of death: -
Type of inheritance: autosomal dominant
External references:
1 OMIM reference -
1 MeSH reference: C538155
Gene symbol UniProt reference OMIM reference
HOXD13 P35453142989
Very frequent
- Autosomal dominant inheritance
- Metacarpal anomalies / Archibald's sign
- Terminal / third phalangeal bone of fingers hypoplasia
- Ulnar deviation of fingers

Frequent
- Camptodactyly of fingers
- Syndactyly of fingers / interdigital palm
- Syndactyly of toes

Occasional
- Clinodactyly of fifth finger